Reduced acute inflammatory responses to microgel conformal coatings

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Reduced acute inflammatory responses to microgel conformal coatings.

Implantation of synthetic materials into the body elicits inflammatory host responses that limit medical device integration and biological performance. This inflammatory cascade involves protein adsorption, leukocyte recruitment and activation, cytokine release, and fibrous encapsulation of the implant. We present a coating strategy based on thin films of poly(N-isopropylacrylamide) hydrogel mi...

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Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly(N-isopropylacrylamide) hydrogel microparticles cross-linked with poly(ethylene glycol) diacrylate deposited on p...

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ژورنال

عنوان ژورنال: Biomaterials

سال: 2008

ISSN: 0142-9612

DOI: 10.1016/j.biomaterials.2008.08.015